𝐅𝐫𝐨𝐦 𝐦𝐢𝐜𝐫𝐨𝐚𝐫𝐜𝐡𝐢𝐭𝐞𝐜𝐭𝐮𝐫𝐞 𝐭𝐨 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐜𝐬 𝐚𝐧𝐝 𝐟𝐫𝐨𝐦 𝐛𝐢𝐨𝐦𝐚𝐫𝐤𝐞𝐫𝐬 𝐭𝐨 𝐡𝐢𝐬𝐭𝐨𝐥𝐨𝐠𝐲 : 𝑒𝑥 𝑣𝑖𝑣𝑜 analyses are key to understanding 𝐛𝐨𝐧𝐞 𝐭𝐨𝐱𝐢𝐜𝐢𝐭𝐲.
Understanding drug-induced effects on bone requires more than systemic endpoints. 𝐸𝑥 𝑣𝑖𝑣𝑜 analyses provide 𝐜𝐫𝐢𝐭𝐢𝐜𝐚𝐥 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐛𝐨𝐧𝐞 𝐪𝐮𝐚𝐥𝐢𝐭𝐲, 𝐬𝐭𝐫𝐞𝐧𝐠𝐭𝐡, 𝐚𝐧𝐝 𝐫𝐞𝐦𝐨𝐝𝐞𝐥𝐢𝐧𝐠 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬.

At Atlantic Bone Screen, we combine complementary 𝑒𝑥 𝑣𝑖𝑣𝑜 approaches to deliver a 𝐫𝐨𝐛𝐮𝐬𝐭 𝐚𝐧𝐝 𝐭𝐫𝐚𝐧𝐬𝐥𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐚𝐬𝐬𝐞𝐬𝐬𝐦𝐞𝐧𝐭 𝐨𝐟 𝐛𝐨𝐧𝐞 𝐭𝐨𝐱𝐢𝐜𝐢𝐭𝐲:
🔬 Micro-Computed Tomography (µCT) : High-resolution analysis of 𝐛𝐨𝐧𝐞 𝐦𝐢𝐜𝐫𝐨𝐚𝐫𝐜𝐡𝐢𝐭𝐞𝐜𝐭𝐮𝐫𝐞 (trabecular and cortical parameters) > know more
🦴 Three-Point Bending Test : Evaluation of whole 𝐛𝐨𝐧𝐞 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐜𝐚𝐥 𝐬𝐭𝐫𝐞𝐧𝐠𝐭𝐡 and intrinsic material properties
🧪 ELISA Assays : Quantification of 𝐛𝐨𝐧𝐞 𝐭𝐮𝐫𝐧𝐨𝐯𝐞𝐫 𝐛𝐢𝐨𝐦𝐚𝐫𝐤𝐞𝐫𝐬 to assess resorption and formation dynamics > know more
🧫 Histological Evaluation : Detailed 𝐜𝐞𝐥𝐥𝐮𝐥𝐚𝐫 𝐚𝐧𝐝 𝐬𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐚𝐥 𝐚𝐬𝐬𝐞𝐬𝐬𝐦𝐞𝐧𝐭 𝐨𝐟 𝐛𝐨𝐧𝐞 𝐭𝐢𝐬𝐬𝐮𝐞 and remodeling activity > know more

By integrating 𝐬𝐭𝐫𝐮𝐜𝐭𝐮𝐫𝐚𝐥, 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐜𝐚𝐥, 𝐛𝐢𝐨𝐜𝐡𝐞𝐦𝐢𝐜𝐚𝐥, 𝐚𝐧𝐝 𝐡𝐢𝐬𝐭𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐝𝐚𝐭𝐚, we support our partners in generating high-quality, decision-enabling preclinical bone safety data.
👉 Each of those techniques highlights the depth and complementarity of our 𝑒𝑥 𝑣𝑖𝑣𝑜 expertise