🔬 𝐄𝐱𝐩𝐥𝐨𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐫𝐨𝐥𝐞 𝐨𝐟 𝐌𝟏 𝐦𝐚𝐜𝐫𝐨𝐩𝐡𝐚𝐠𝐞𝐬 𝐢𝐧 𝐬𝐤𝐢𝐧 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐢𝐨𝐧
Did you know that M1 macrophages play a key role in the pathogenesis of 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐬𝐤𝐢𝐧 𝐝𝐢𝐬𝐞𝐚𝐬𝐞𝐬?
Understanding their behavior is thus essential to develop effective treatments.

Here’s why this research axis matters:
✅ 𝐈𝐦𝐦𝐮𝐧𝐞 𝐝𝐞𝐟𝐞𝐧𝐬𝐞 : M1 macrophages secrete pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6, IL-8) to defend the skin against pathogens.
✅ 𝐈𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐢𝐨𝐧 𝐢𝐧𝐢𝐭𝐢𝐚𝐭𝐢𝐨𝐧 : they are among the first responders to injury or infection, triggering local inflammation and promoting tissue repair.
✅ 𝐂𝐡𝐫𝐨𝐧𝐢𝐜 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐢𝐨𝐧 : in conditions such as psoriasis or eczema, persistent M1 activation contributes to sustained inflammation and tissue damage.
✅ 𝐖𝐨𝐮𝐧𝐝 𝐡𝐞𝐚𝐥𝐢𝐧𝐠 : while crucial in early stages, excessive M1 activation can impair healing and lead to fibrosis or scarring.

🧪 Our in vitro approach:
We stimulate M1 macrophages with inflammatory triggers (e.g., LPS) to mimic the immune response. We measure cytokine release and assess gene expression via RT-qPCR to evaluate the anti-inflammatory potential of new compounds.
This model is a 𝐩𝐨𝐰𝐞𝐫𝐟𝐮𝐥 𝐭𝐨𝐨𝐥 𝐭𝐨 𝐬𝐜𝐫𝐞𝐞𝐧 𝐚𝐧𝐝 𝐜𝐡𝐚𝐫𝐚𝐜𝐭𝐞𝐫𝐢𝐳𝐞 𝐭𝐡𝐞𝐫𝐚𝐩𝐢𝐞𝐬 𝐭𝐚𝐫𝐠𝐞𝐭𝐢𝐧𝐠 𝐢𝐦𝐦𝐮𝐧𝐞 𝐩𝐚𝐭𝐡𝐰𝐚𝐲𝐬 𝐢𝐧𝐯𝐨𝐥𝐯𝐞𝐝 𝐢𝐧 𝐬𝐤𝐢𝐧 𝐝𝐢𝐬𝐨𝐫𝐝𝐞𝐫𝐬.

➡️ Are you working on skin inflammation and looking for a reliable preclinical partner? Let’s connect and explore how our macrophage-based in vitro assays can support your research!
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