Pathological models mimicking human and animal pathologies such as osteoporosis, osteoarthritis, rheumatoid arthritis...
Skin health
Expertise and protocols adapted to Dermocosmetics needs
Our advanced preclinical platforms provide robust and scientifically validated models for dermatology and cosmetic studies. These models enable a comprehensive evaluation of skin biology and the effects of active ingredients and drug candidates, ensuring precise and reliable data for your research needs.
Our expertise and models can be applied either for drug candidate evaluation or for cosmetics characterization. Read-out, number of replicates and protocols are adapted to match our Customers needs keeping an high added value and strong quality insurance and traceability of the samples and compounds we test.
Either working on 3D skin explants from healthy donors or from patients, or with in vitro protocols on human cells such as keratinocytes (NHEK) or fibrobasts or macrophages.
With a commitment to quality and client-focused research, our models are tailored to meet the specific needs of your dermatology and cosmetic projects. Whether you’re exploring anti-aging products, wound healing agents, or inflammatory skin conditions, our expertise ensures accurate and robust results.
Skin Explant Models
We use ex vivo human skin explants, which preserve the structural and functional integrity of all skin layers, including the epidermis, dermis, and hypodermis. This model is ideal for studying:
- The effects of active ingredients on skin barrier function, hydration, and elasticity.
- Complex interactions with immune cells or external factors
- Epidermal differentiation
Know more on our skin explants model
Cellular Models
Our in vitro platforms employ primary keratinocytes and fibroblasts to simulate the skin’s cellular microenvironment. These models can be used for testing and mechanistic studies, focusing on:
- Collagen and elastin synthesis
- Cytotoxicity
- Cellular proliferation and migration
- Oxidative stress / induced damage responses
Diverse analysis techniques for Skin Research
Our team has access to a wide variety of analysis techniques for your skin research. Our expertise includes:
- ELISA Analyses: for the detection and quantification of proteins
- qPCR Analyses: for precise quantification of RNA, aiding in the understanding of gene expression in skin cells or in skin explant.
- Skin biopsies analysis: using histological techniques to examine skin tissue for structural and cellular changes.
We offer a catalog of over 75 histological markers, providing insights into all skin layers and appendages, including:
- Epidermal and dermal structure.
- Follicular health and pigmentation.
- Immune cell infiltration and inflammatory processes.
Our advanced histological techniques ensure precise quantification and visualization, supporting the development of innovative dermatological and cosmetic solutions.
Know more on our skin histology services
We are dedicated to employing these techniques to provide high-quality results tailored to our clients’ needs in skin research and development.
Validated assays for in vitro cytotoxicity and in vivo biocompatibility evaluation in regenerative medicine; also animal implantation models to validate...
Preclinical models applied to inflammatory diseases to better understand mechanism of actions of compounds and treatment efficacy
Robust models on tumoral cell lines and in vivo oncological models to validate future drugs for bone cancer, bone metastases...