Ligerin (1) is a natural chlorinated merosesquiterpenoid related to fumagillin (2) exhibiting a selective antiproliferative activity against osteosarcoma

New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance Chondrosarcomas are cartilage-forming,

Aim: To investigate the in vivo efficacy of a novel polybisphosphonate (ODX) in the treatment of bone metastasis